Opisthorchis felineus rivolta, 1884 is a member of the triad of epidemiologically important fishborne liver trematodes, which also includes o. Trematodes clonorchis sinensis and fasciola hepatica. Opisthorchis viverrini is the biggest causative organism for this disease. Clonorchis sinensis is the major liver fluke found in p. Clonorchis sinensis is a zoonotic parasite causing clonorchiasisassociated human disease such as biliary calculi, cholecystitis, liver cirrhosis, and it is currently classified as.
Pdf specific and common antigens of clonorchis sinensis. Expanded complement of niemannpick type c2like protein. Uncooked fish consumption among those at risk of opisthorchis. A high prevalence has been reported in byelorussia, russia, and the ukraine. Epidemiology of opisthorchis viverrini in an endemic area of. Lightly salted, smoked, or pickled fish can contain infectious parasites. The draft genome of the carcinogenic human liver fluke. Trematode parasites of the genera clonorchis, opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which. Synopsisofthespeciesoncenamedinthegenus opdahorchiaandtheredivisionintothreegenera. Identification and characterization of clonorchis sinensis cathepsin. Opisthorchis viverrini and clonorchis sinensis were considered by a previous iarc working group in 1994 iarc, 1994. Infection with the parasite is called opisthorchiasis.
Opisthorchis viverrini ov, a human liver fluke, is a pathologically and economically important foodborne trematode. Dec, 2018 opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the southeast asian liver fluke called as opisthorchis viverrini. Pronunciation of clonorchis sinensis with 1 audio pronunciation, 1 meaning and more for clonorchis sinensis. Opisthorchis felineus is a trematode that is transmitted to humans through the consumption of raw freshwater fish of the family cyprinidae. In 1874, a 20 year old chinese carpenter was admitted to the medical college hospital.
Wed like to understand how you use our websites in order to improve them. Detection of opisthorchis viverrini in experimentally infected bithynid snails and cyprinoid fishes by a pcrbased method volume 126 issue 1 w. Clonorchis sinensis, opisthorchis viverrini and opisthorchis felineus are three closely related species that produce similar clinical manifestations in humans. Medical care and loss of wages caused by opisthorchis viverrini in laos and. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Identification and characterization of micrornas in. Start studying trematodes clonorchis sinensis and fasciola hepatica.
Media in category clonorchis sinensis the following 9 files are in this category, out of 9 total. In 1891, russian parasitologist, konstantin nikolaevich vinogradov 18471906 2 found it in a human, and named the parasite a siberian liver fluke. An opisthorchiid liver fluke was recently reported from ducks anas platyrhynchos in binh dinh province of central vietnam, and referred to as opisthorchis viverrinilike. Infections with the opisthorchid liver flukes clonorchis sinensis, opisthorchis viverrini, and o.
The first intermediate hosts of clonorchis sinensis and opisthorchis viverrini in different countries. Updated molecular phylogenetic data for opisthorchis spp. The fda recommends the following for fish preparation or storage to kill any parasites. In this study, we refer to the liver fluke from ducks as. Currently, it is estimated that more than 200 million people are at risk of c. In this study we evaluate a pcrbased molecular identification method, multiplex ligationdependent probe. This species uses common cyprinoid fishes as second intermediate hosts as does opisthorchis viverrini, with which it is sympatric in this province. Opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the. Clonorchis sinensis an overview sciencedirect topics. Current status and perspectives of clonorchis sinensis and. Clonorchis sinensis, opisthorchis spp, and metorchis spp. Pdf opisthorchis viverrini and opisthorchis felineus.
Opisthorchis definition of opisthorchis by medical. Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family opisthorchiidae. Plasma metabolomics of the time resolved response to. Oct 24, 2011 clonorchis sinensis is a carcinogenic human liver fluke that is widespread in asian countries. Increasing infection rates of this neglected tropical disease are leading to negative economic and public health consequences in affected regions. An integrated epidemiological study of opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment.
The present study developed an assay integrating realtime pcr and high resolution melting hrm analysis for the specific detection and rapid identification of c. Opisthorchis infection can be prevented by avoiding raw or undercooked freshwater fish. Clonorchis sinensis infectious diseases of poverty biomed central. Our molecular resources now underpin profound explorations of opisthorchiasis cca and the design of new interventions. The oral and ventral suckers acetabulum are relatively small. Opisthorchiasis and opisthorchisassociated cholangiocarcinoma in. Detection of opisthorchis viverrini in experimentally.
Clonorchis sinensis wikipedia, a enciclopedia livre. Fish sharing as a risk factor for opisthorchis viverrini. Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct. The distribution of the vitelline glands is also different.
More than one stool sample may be needed to detect the eggs. Clonorchis sinensis adults are flattened, lance shaped, and measure approximately 10 to 25 mm long by 3 to 5 mm wide. These species of flukes are classified as group i carcinogens by the international agency for research on cancer iarc. The liver flukes, opisthorchis viverrini and clonorchis sinensis, are known to cause cholangiocarcinoma cca, a type of liver cancer that develops within the bile duct. Epidemiology of opisthorchis viverrini in an endemic area. Worldwide, the number of cases of human infection has been estimated to be 1. May first report and molecular identification of opisthorchis viverrini infection in human communities from lower myanmar win pa pa aung 0 1 2 thi thi htoon 0 2 htay htay tin 0 2 kyi kyi thinn 0 2. The parasitic flatworm clonorchis sinensis inhabits the biliary tree of humans and other piscivorous mammals. Prevalence of intestinal parasitic infections in 2012, c. Some of these parasites are highly associated with cholangiocarcinoma. Comparison of infectivity, metacercarial burden and host. Worldwide, the number of cases of human infection has.
Dao, thanh thi ha, thanh thi giang nguyen, sarah gabriel, khanh linh bui, pierre dorny, and thanh hoa le. Liver fluke clonorchis sinensis is a high risk pathogenic parasitic. The opisthorchis viverrini genome provides insights into life in the. Molecular identification of clonorchis sinensis and. Which of the following infections involves intermediate.
Download scientific diagram suppression of mrnas encoding cd63 family tetraspanins from the. After ingestion of undercooked fish or crab, the metacercariae excyst in the small. Reinfection of dogs with fishborne zoonotic trematodes in. Clonorchis sinensis, the chinese liver fluke, is a liver fluke belonging to the class trematoda, phylum platyhelminthes. An opisthorchiid liver fluke was recently reported from ducks anas platyrhynchos in binh dinh. Clonorchis sinensis and opisthorchis species are important liver flukes of oriental or chinese origin 14. Gene discovery for the carcinogenic human liver fluke. In vitro diagnostic for the liver flukes opisthorchis. Two human liver flukesnamely, clonorchis sinensis and opisthorchis. Clonorchiasis whose symptoms are indistinguishable from opisthorchiasis is one of the most neglected tropical diseases which blight the lives of millions of people worldwide and threaten the health of several others 5, 6. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. The three epidemiologically important opisthorchiidae liver flukes opisthorchis felineus, o.
Jul 18, 2018 the liver flukes, opisthorchis viverrini and clonorchis sinensis, are known to cause cholangiocarcinoma cca, a type of liver cancer that develops within the bile duct. Sebastiano rivolta is generally credited with discovering the first opisthorchid, which he named distoma felineus, in a cat in italy in 1884. China, 2 key laboratory of parasite and vector biology, ministry of health. Opisthorchis 20200430 20200430 tagged figure adult opisthorchis viverrini flukes in humans. An integrated epidemiological study of opisthorchis viverrini consisting of risk factors analysis and parasitation prevalence determination in humans, as well as the assessment the roles of host reservoirs dogs and cats and intermediate hosts cyprinid fish was carried out in the vicinity of huay luang dam, udon thani province, in the north east of thailand. The two testes are located posterior to the ovary, and are highly brancheda feature which separates it from the related opisthorchis spp. Early identification of the infection is essential to provide timely and appropriate chemotherapy to patients. Together they affect more than 45 million people and 600750 million people are at risk in the endemic regions of eurasia. Human illnesses caused by opisthorchis felineus flukes, italy. Opisthorchis felineus, or cat liver fluke is a trematode parasite that infects the liver in mammals. Since that time, new data have become available, these have been.
Pdf opisthorchis viverrini liver fluke as the lot of baleful parasite. Tetanus differs from botulism in that a tetanus results in flaccid. The human liver fluke, opisthorchis viverrini sensu lato s. The tumorigenic liver fluke opisthorchis viverrinimultiple. Since that time, new data have become available, these have been incorporated in the monograph, and taken into consideration in the present evaluation. Microscopic identification of possible clonorchisopisthorchis infection in two ghanaian women with undiagnosed abdominal discomfort. The antigenic characterizations and serological reactions of human liver flukes, clonorchis sinensis and opisthorchis viverrini, were analyzed by immunoblot. The chinese liver fluke, clonorchis sinensis producing clonorchiasis was first seen in 1874 and described in 1875 by mcconnell in the bile passages of a.
Nov 17, 2014 clonorchis sinensis and opisthorchis species are important liver flukes of oriental or chinese origin 14. Pdf microscopic identification of possible clonorchis. Clonorchiasis whose symptoms are indistinguishable from opisthorchiasis is. From the greek opisthen behind and orchis testicle, opisthorchis is a genus of trematode flatworms whose testes are located in the posterior end of the body. Opisthorchis species are liver fluke parasites that humans can get by eating raw or undercooked fish, crabs, or crayfish from areas in asia and europe where the parasite is found, including thailand, laos, cambodia, vietnam, germany, italy, belarus, russia, kazakhstan, and ukraine. Pdf liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts which is highly prominent in the tropical regions. Foodborne trematodiasis fbt is a significant global health problem, with the liver flukes opisthorchis viverrini, o. It was first discovered in 1884 in a cats liver by sebastiano rivolta of italy. Pdf clonorchis sinensis, an oriental liver fluke, as a human. Clonorchis sinensis and opisthorchis viverrini are both important fishborne pathogens, causing serious public health problem in asia. People are infected after eating raw or undercooked fish. Opisthorchis definition of opisthorchis by medical dictionary.
In humans, it infects the common bile duct and gall bladder, feeding on bile. Experimental and epidemiological studies have shown a strong association between the incidence of cholangiocarcinoma and the infection rate of c. Clonorchis sinensis, opisthorchis viverrini, and o. Opisthorchis felineus an overview sciencedirect topics. Opisthorchis infection does not result from drinking river water or other nonpotable water. Infeetion with livr flukes opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis 1.
First report and molecular identification of opisthorchis. Opisthorchis sinensis definition of opisthorchis sinensis. Humans contract the disease through consumption of raw or inadequately cooked freshwater fish containing. Unlocking the transcriptomes of two carcinogenic parasites, clonorchis sinensis and opisthorchis viverrini.
Nov 21, 2017 an opisthorchiid liver fluke was recently reported from ducks anas platyrhynchos in binh dinh province of central vietnam, and referred to as opisthorchis viverrinilike. Opisthorchis viverrini and clonorchis sinensis biological. Diagnosis of opisthorchis infection is based on microscopic identification of eggs in stool specimens. Opisthorchioidea from ducks in vietnam thanh thi ha dao1,2,3, thanh thi giang nguyen1,2, sarah gabriel4, khanh linh bui5, pierre dorny2,3 and thanh hoa le6 abstract background.
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